Skinade MD INsupport is a nutraceutical supplement specifically formulated to support skin health and enhance the outcomes of dermal filler and botulinum toxin treatments. It contains several key ingredients that promote skin hydration, elasticity, and repair, which can complement the effects of aesthetic procedures like fillers and Botox. Below are the key ingredients and their roles

1. Hydrolyzed Marine Collagen Peptides

• Mechanism: Collagen is a primary structural protein in the dermis, providing tensile strength and resistance to mechanical stress. Hydrolysed marine collagen, due to its low molecular weight, is highly bioavailable and acts as a substrate to stimulate fibroblast activity. This then causes an increase in collagen synthesis.
• Relevance: In dermal filler applications, where augmentation and structural support of the dermis are key, increased collagen synthesis can prolong and enhance the volumising effects. For botulinum toxin treatments, enhanced dermal support contributes to the smoothening of dynamic lines, complementing the toxin’s action on facial muscles.

2. Vitamin C (Ascorbic Acid)

• Mechanism: Ascorbic acid is a cofactor for prolyl hydroxylase and lysyl hydroxylase, enzymes essential in stabilising and crosslinking collagen fibres. Furthermore, it functions as a potent antioxidant, scavenging reactive oxygen species (ROS), thereby preventing oxidative degradation of collagen.
• Relevance: Given that dermal fillers often rely on matrix support provided by extracellular collagen, ascorbic acid’s role in collagen biosynthesis helps sustain the filler’s effect. Additionally, its antioxidative properties protect the skin from free radical damage. This is particularly important after botulinum toxin, where skin integrity must be maintained for optimal wrinkle reduction.

3. B-Vitamin Complex (B2, B3, B5, B7)

• Mechanism:
  • Vitamin B2 (Riboflavin): A coenzyme in redox reactions, crucial for tissue regeneration.
  • Vitamin B3 (Niacinamide): Enhances the production of ceramides, improving barrier function and reducing trans-epidermal water loss.
  • Vitamin B5 (Pantothenic Acid): Precursor of CoA, necessary for lipid metabolism, which contributes to skin hydration.
  • Vitamin B7 (Biotin): Involved in fatty acid metabolism, critical for maintaining epidermal integrity.
• Relevance: By enhancing epidermal barrier function and promoting tissue regeneration, these vitamins facilitate quicker recovery post-injection, maintain hydration, and improve overall skin texture, thus amplifying the aesthetic outcomes of both fillers and Botox treatments.

4. L-Lysine

• Mechanism: Essential for collagen cross-linking through its role in the hydroxylation of proline, contributing to stronger collagen fibre networks.
• Relevance: L-Lysine’s role in collagen biosynthesis and crosslinking supports dermal architecture, thereby enhancing filler integration and durability. Post-BoNT treatment, lysine aids in maintaining dermal structure by facilitating tissue repair.

5. MSM (Methylsulfonylmethane)

• Mechanism: MSM donates sulphur, a crucial element for collagen synthesis. It has been demonstrated to modulate inflammatory responses through downregulation of NF-κB pathways.
• Relevance: MSM’s contribution to dermal collagen synthesis and its anti-inflammatory properties are particularly advantageous in dermal fillers, where maintaining dermal thickness and reducing post-injection inflammation are desired outcomes. Additionally, by minimising inflammation, it helps prevent erythema or oedema often observed after dermal filler injections.

6. Omega 3 and Omega 6 Essential Fatty Acids

• Mechanism: These fatty acids are crucial components of cell membranes and contribute to the formation of lipid barriers in the stratum corneum. They also have anti-inflammatory effects via modulation of eicosanoid production.
• Relevance: For dermal fillers, these fatty acids enhance skin hydration and barrier function, creating an optimal extracellular environment for filler integration. For BoNT treatments, the reduction of inflammation supports smoother recovery, minimising adverse effects like erythema and swelling.

7. Hyaluronic Acid Precursor (Glucosamine)

• Mechanism: Glucosamine is a substrate for glycosaminoglycan (GAG) synthesis, particularly hyaluronic acid, a key component of the extracellular matrix. It maintains skin hydration and volume.
• Relevance: Many dermal fillers are composed of hyaluronic acid. Thus, supplying the skin with precursors for natural hyaluronic acid production aids in maintaining skin hydration and enhancing filler integration. For botulinum toxin treatments, increasing hyaluronic acid levels contributes to skin smoothness and elasticity, complementing the neuromodulatory effects of BoNT.

8. Zinc

• Mechanism: Zinc is involved in DNA synthesis, cellular proliferation, and enzymatic functions critical for wound healing and collagen stabilisation. It also plays a role in controlling inflammation.
• Relevance: Post-injection, zinc facilitates tissue repair and collagen stabilisation, important for maintaining the structural integrity imparted by fillers. Zinc’s anti-inflammatory properties also reduce post-injection swelling and erythema, optimising aesthetic outcomes from BoNT treatments.

9. L-Glutamine

• Mechanism: L-Glutamine is a critical amino acid for cellular proliferation and tissue repair. It also plays a role in nitrogen balance and supports the immune system, enhancing the body’s ability to respond to tissue injury.
• Relevance: Post-injection, L-Glutamine accelerates wound healing and skin regeneration, ensuring faster recovery and potentially extending the lifespan of dermal fillers by supporting tissue health. For botulinum toxin treatments, it aids in skin repair and maintaining optimal skin conditions.

10. Astaxanthin

• Mechanism: Astaxanthin is a potent antioxidant, quenching singlet oxygen and reducing lipid peroxidation. It also enhances cellular function by protecting mitochondria from oxidative damage.
• Relevance: By preventing oxidative damage to skin cells and extracellular components, astaxanthin supports the integrity of the dermal matrix, enhancing the durability of dermal fillers and providing an anti-inflammatory environment post-BoNT treatment. This helps mitigate signs of aging and prolong the efficacy of both treatments.

11. Coenzyme Q10 (CoQ10)

• Mechanism: CoQ10 is integral to mitochondrial ATP production and functions as an endogenous antioxidant, protecting cells from oxidative stress and aiding in tissue repair.
• Relevance: Enhanced mitochondrial function and reduced oxidative stress are vital for maintaining the post-injection health of dermal and epidermal cells. CoQ10, therefore, supports skin rejuvenation post-Botox and fillers by energizing cellular processes essential for repair and regeneration.

12. Alpha Lipoic Acid (ALA)

• Mechanism: ALA is both a fat- and water-soluble antioxidant, capable of regenerating other antioxidants such as Vitamin C and E, and reducing oxidative stress at a cellular level.
• Relevance: ALA’s antioxidative role helps protect the skin’s cellular environment from oxidative stress, which is critical in preserving the structural effects of dermal fillers and minimizing the skin’s reaction to botulinum toxin injections. It also plays a role in modulating inflammation, further supporting recovery.

13. Quercetin

• Mechanism: Quercetin functions as a powerful free radical scavenger, inhibiting oxidative damage to cells by neutralizing reactive oxygen species (ROS). Additionally, it has been shown to inhibit pro-inflammatory mediators such as NF-κB, COX-2, and pro-inflammatory cytokines like IL-1β and TNF-α. Quercetin also enhances mitochondrial biogenesis and function, further supporting tissue health.
• Relevance: In the context of dermal fillers and botulinum toxin (BoNT) treatments, quercetin’s antioxidative properties help protect the dermal matrix from oxidative damage that can degrade hyaluronic acid and collagen, both critical for the longevity of filler results. Its anti-inflammatory action mitigates post-procedural inflammation, reducing swelling and erythema that can follow filler or BoNT injections. Quercetin also aids in enhancing skin resilience and repair, potentially improving recovery times and maintaining skin health, which is essential for achieving optimal aesthetic outcomes.

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Conclusion:

The ingredients in Skinade MD INsupport are formulated based on robust biochemical principles to optimise dermal health and enhance the outcomes of dermal fillers and botulinum toxin treatments. By targeting critical pathways in collagen biosynthesis, tissue repair, hydration, and inflammation control, these compounds provide a scientifically sound adjunct to aesthetic interventions, supporting improved efficacy, longevity, and recovery from these procedures.

You can buy Skinade MD INsupport here or call one of our team to help you on 01582762877. For pre and post surgery support click here.

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